Abstract

Different brands of Ginkgo Biloba standardized extract available in the Bangladeshi market are widely used for the symptomatic treatment of cognitive dysfunction, dementia, Alzheimer’s disease, etc. This study was conducted to evaluate the quality of two Ginkgo Biloba capsule dosage forms; one is from a mainstream pharmaceutical company (sample 2) and another is from a recognized herbal drug manufacturing company (sample 1). To assess their quality, the qualitative and quantitative analysis of the flavonoid content of the selected products were performed by HPLC followed by antioxidant activity determination using different antioxidant activity study methods.HPLC analysis of them identified the presence of two principal flavonoids; quercetin and kaempferol in the quantity of 6.01 and 0.29 mg in sample 2; and 1.34 and 0.28 mg in sample 1. Thus, the HPLC analysis revealed that the quantity of quercetin and kaempferol present in sample 2 was higher than in sample 1. In the DPPH assay, sample 2 showed higher DPPH free radical scavenging power with an IC50 of 0.34 mg/mL than sample 1 with an IC50 of 0.57 mg/mL Moreover, sample 2 showed higher TPC, TFC, and TAC than sample 1.