Abstract

This study sought to investigate the protective effects of Mimosa pudica leaves extract on CCl4-intoxicated hepatic inflammation and fibrosis in Long-Evans rats. Rat liver developed fibrosis, inflammation, and oxidative stress due to CCl4 administration. Rats given CCl4 showed increased levels of nitric oxide (NO), advanced oxidation protein product (AOPP), and malondialdehyde (MDA), and these were followed by decreased glutathione (GSH) levels and catalase activity. Mimosa pudica extract treatment showed significant reduction in oxidative stress parameters, lowered myeloperoxidase (MPO) activities, and improved endogenous antioxidant enzyme activities in rats intoxicated with CCl4. Furthermore, Mimosa pudica as a treatment avoided the obvious expression of inflammation and fibrosis in the liver of CCl4 administered rats. In conclusion, Mimosa pudica may prevent oxidative stress, inflammation, and fibrosis in the liver of rats given CCl4; it is probable that increasing the activity of antioxidant enzymes is how this protective effect is achieved.